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SMART Digest compared to classic in-solution digestion of rituximab for in-depth peptide mapping characterization
![smart digest evaluation](/Image/AppImage/3697/20170118125614/smart-digest-evaluation?imageNameOnDisk=758163ee-fd7e-4e9f-8bca-35446cdecdd8-8e0ac33c-8ef7-48e5-8c04-119ffc4cc48d.png)
Description
This study compares the newly developed Thermo Scientific™ SMART Digest™ kit to classic in-solution protein digestion methods, focusing on protein sequence coverage and identified post-translational modifications (PTMs), including deamidation, oxidation, and glycosylation. A Thermo Scientific™ Acclaim™ VANQUISH™ C18 column with conventional water/acetonitrile-based gradients and the Thermo Scientific™ Vanquish™ Flex UHPLC system were used for separation in combination with the Thermo Scientific™ Q Exactive™ HF Hybrid Quadrupole-Orbitrap™ mass spectrometer.Market: | BioPharma |
Keywords: | Monoclonal antibody, Peptide mapping, Vanquish, Tryptic digest, Biopharmaceutical, mass spectrometry, mAb, Q Exactive, Biomolecules, Reversed phase, Orbitrap, SMART Digest kit, in-solution protein digestion |
Matrix: | Drug product |
Author: | Martin Samonig; Alexander Schwahn; Ken Cook; Mike Oliver; Remco Swart |
Affiliation: | Thermo Fisher Scientific |
For Research Use Only. Not for use in diagnostic procedures.