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Displaying 1-5 of 15 results for Tag: Drug Product
AN327: Extraction of Nitroglycerin from Transdermal Patches by Accelerated Solvent ExtractionInstrument Type: Automated Sample Prep
Accelerated solvent extraction is an extraction method that significantly streamlines sample preparation. Solvent is pumped into an extraction cell containing the sample, which is then brought to an elevated temperature and pressure. The entire extraction process is fully automated and performed in minutes for fast and easy extraction with low solvent consumption. The work reported here was undertaken to investigate the use of accelerated solvent extraction for the extraction of nitroglycerin from prototype transdermal matrix patches.
SMART Digest compared to classic in-solution digestion of rituximab for in-depth peptide mapping characterizationInstrument Type: LCMS
This study compares the newly developed Thermo Scientific™ SMART Digest™ kit to classic in-solution protein digestion methods, focusing on protein sequence coverage and identified post-translational modifications (PTMs), including deamidation, oxidation, and glycosylation. A Thermo Scientific™ Acclaim™ VANQUISH™ C18 column with conventional water/acetonitrile-based gradients and the Thermo Scientific™ Vanquish™ Flex UHPLC system were used for separation in combination with the Thermo Scientific™ Q Exactive™ HF Hybrid Quadrupole-Orbitrap™ mass spectrometer.
Tandem UHPLC operation for high-throughput LC-MS peptide mapping analysesInstrument Type: LCMS
To demonstrate the use of a multi-pump UHPLC system and enable tandem analysis with two columns in parallel, addressing productivity and throughput improvement of existing LC-MS methods.
High resolution charge variant analysis of Cetuximab by ion exchange chromatography using pH gradient buffersInstrument Type: HPLC (Biocompatible)
The Thermo Scientific MAbPac SCX-10 column is applied to the charge variant analysis of Cetuximab. Ion exchange separation was performed using a pH gradient on a Thermo Scientific Vanquish Flex UHPLC system with UV detection at 280 nm. Use of Thermo Scientific CX-1 pH gradient buffers enabled high resolution separation of monoclonal antibody charge variants over a 30 minute gradient.
High resolution charge variant analysis of Infliximab by ion exchange chromatography using pH gradient buffersInstrument Type: HPLC (Biocompatible)
The Thermo Scientific MAbPac SCX-10 column is applied for charge variant analysis of Infliximab. Ion exchange separation was performed on a Vanquish Flex UHPLC system using a pH gradient and UV detection at 280 nm. Use of Thermo Scientific CX-1 pH gradient buffers enabled high resolution separation of monoclonal antibody charge variants over a 30 minute gradient.