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A universal chromatography method for aggregate analysis of monocolonal antibodies
DescriptionAnalysis of protein aggregation of five important biotherapeutic monoclonal antibodies (mAbs) by size-exclusion chromatography, showing the universal applicability of the Thermo Scientific MAbPac SEC-1 column for aggregate analysis of mAbs. The biopharmaceutical industry continues to develop mAb-based biotherapeutics have several key quality attributes that require quantification. This shows the ability to determine quickly and accurately the percentage of aggregates and fragments for five therapeutics as shown with full details in the AN21601 download.
|Keywords:||Biotherapeutics, Monoclonal antibody, Size-Exclusion Chromatography, MAbPac SEC-1, Bevacizumab, Rituximab, Aggregation analysis, Infliximab, Cetuximab, Trastuzumab, NIBRT, Bioprocessing Research|
|Author:||Amy Farrell, Jonathan Bones, and Ken Cook|
|Affiliation:||NIBRT, Dublin, Ireland|
|Status:||Proof of Concept|
For Research Use Only. Not for use in diagnostic procedures.