AN1072: Ion Chromatography Assay for Ammonia in Adenosine
DescriptionAdenosine is produced by the condensation of ribose and adenine biochemically or by fermentation. Ammonia is an impurity in adenosine preparations and the U.S. Pharmacopeia (USP) adenosine monograph describes an assay to determine the amount of ammonia in adenosine by comparing the color of an adenosine sample and a ammonium chloride standard solution after the addition of an alkaline mercuric/potassium iodide solution to each. This application is an ion chromatography (IC)-based method that can meet the assay requirements and replace the USP adenosine monograph’s color-based method.
|Keywords:||Adenosine, Ammonia, Dionex IonPac CS12A, Drug Products, Fast Separation, Impurities, Pharmaceutical, Reagent-Free Ion Chromatography, RFIC, Suppressed Conductivity|
For Research Use Only. Not for use in diagnostic procedures.