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AN1072: Ion Chromatography Assay for Ammonia in Adenosine Be the first to rate this application

an1072 ion chromatography assay for ammonia adenosine


Adenosine is produced by the condensation of ribose and adenine biochemically or by fermentation. Ammonia is an impurity in adenosine preparations and the U.S. Pharmacopeia (USP) adenosine monograph describes an assay to determine the amount of ammonia in adenosine by comparing the color of an adenosine sample and a ammonium chloride standard solution after the addition of an alkaline mercuric/potassium iodide solution to each. This application is an ion chromatography (IC)-based method that can meet the assay requirements and replace the USP adenosine monograph’s color-based method.
Market: Pharma
Keywords: Adenosine, Ammonia, Dionex IonPac CS12A, Drug Products, Fast Separation, Impurities, Pharmaceutical, Reagent-Free Ion Chromatography, RFIC, Suppressed Conductivity
Matrix: Drug
Uploaded on 3/12/2015.

For Research Use Only. Not for use in diagnostic procedures.