Find methods for your needs
Refine by Feature
Displaying 1-5 of 38 results for Tag: Drug
Assay analysis of Amoxicillin and Clavulanate Potassium as per USPInstrument Type: HPLC
The Thermo Scientific Dionex UltiMate 3000 LC system is applied for the analysis of Amoxicillin and Clavulanate Assay as per USP. The analysis was performed on a Thermo Scientific Syncronis aQ L1 HPLC column using the method described in the USP 40 monograph. The results obtained were found to be within acceptance criteria as stated in the USP. Resolution between Amoxicillin and clavulanic acid was 14.0 (USP criteria: not less than 3.5). Tailing Factors observed were 0.84 & 1.25 respectively (USP criteria: not more than 1.5 for each analyte). RSD found to be less than 2% for both analytes
A pre-concentration and on-line solid phase extraction setup for the LC-MS analysis of therapeutic protein mixturesInstrument Type: LCMS
This study shows a fully automated UHPLC setup applying a simple and efficient online solid phase extraction method. Showcase assay performance by using a column cartridge for sample trapping and a Thermo Scientific™ MAbPac™ RP column for separation with water/acetonitrile-based gradients. Leverage the new technologies such as the Thermo Scientific™ Vanquish™ UHPLC platform in combination with the Thermo Scientific™ Q Exactive™ HF Hybrid Quadrupole Orbitrap mass spectrometer.
AU205: Assay for Citrate and Phosphate in Pharmaceutical Formulations Using a High-Pressure Compact Ion Chromatography SystemInstrument Type: IC
Using ion chromatography methods to determine citrate and phosphate in pharmaceutical formulations has been previously demonstrated, validated, and adopted by The United States Pharmacopeia (USP) in General Chapter< 345>. The monograph specified an L61 column. Here we demonstrate that a higher porosity, higher capacity, and smaller particle size L81 column with similar selectivity to L61 has much higher efficiencies, capacities, and sensitivities, and extended linear range with reduced run times.
Determination of Sulfate and Sulfamate in Topiramate Using a Compact Reagent-Free Ion Chromatography SystemInstrument Type: IC
Determination of sulfamate and sulfate are used to monitor and confirm topiramate degradation. In application note 238 we demonstrate the use of a Reagent-Free Ion Chromatography (IC) system with a Thermo Scientific Dionex IonPac AS11 column and suppressed conductivity detection for the determination of sulfamate and sulfate in topiramate. This record shows that the method can be run using a new compact IC system: the Thermo Scientific Dionex Integrion system.
Assay for Citrate and Phosphate in Pharmaceutical Formulations Using a Compact IC SystemInstrument Type: IC
Citric acid is a common ingredient found in pharmaceutical formulations. An assay for citrate and phosphate in pharmaceutical formulations using ion chromatography with a Thermo Scientific Dionex IonPac AS11 hydroxide-selective, anion-exchange column and suppressed conductivity detection was validated in Application Note 164. The method incorporates an electrolytic eluent generator to automatically produce an isocratic potassium hydroxide eluent. This record shows that the method can be run using the Thermo Scientific Dionex Integrion system.