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Separation of Acidic and Basic charge variants of Denosumab by Ion Exchange chromatography using Salt Gradient Method Be the first to rate this application


The Thermo Scientific Dionex UltiMate 3000 LC Bio-LC system is applied for the Ion Exchange analysis of Denosumab. The separation was performed on a Thermo Scientific MabPac SCX-10 column with a UV detection at 220 nm. With a run time of 65 minutes the method allows easy separation of charge variants of Denosumab.
Market: BioPharma
Keywords: HPLC, MAbPac SCX-10 Column, Denosumab, PDA detection, Charge Variants, Salt Gradient
Matrix: N/A
Author: Manish Singh
Affiliation: Thermo Fisher Scientific, APAC CoE Lab, Ahmedabad, India
Uploaded on 9/28/2016.

For Research Use Only. Not for use in diagnostic procedures.