Rate
Ask the Expert
Suggest an Application
Add to Favorites
CreateParts List
Tell a Friend
PrintFind methods for your needs
AU178: A Faster Solution with Increased Resolution for Determining Chromatographic Identity and Absence of OSCS in Heparin Sodium
Description
Here, an improved method for resolving DS and OSCS in heparin with an IonPac AS11-HC (2 × 250 mm) column is demonstrated, which is similar to the US FDA method previously described. AU178 updates Application Note 235. The higher capacity of the IonPac AS11-HC column, relative to the IonPac AS11 column described in the current USP method, minimizes the possibility of column overload and provides improved resolution between DS and heparin. The microbore column format reduces eluent consumption and hence the time and labor required for manual eluent preparation.| Market: | BioPharma |
| Keywords: | Chondroitin Sulfate, AU 178, Dermatan Sulfate, IonPac AS11-HC, USP Monograph, Thrombosis, AN235 |
| Matrix: | Water |
| Author: | Terri Christison, Brian De Borba, and Jeff Rohrer |
| Affiliation: | Thermo Fisher Scientific, Sunnyvale, CA USA |
For Research Use Only. Not for use in diagnostic procedures.
