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AN262: Determination of 2-Ethylhexanoic Acid Impurity in Clavulanate
![an262 determination 2ethylhexanoic acid impurity clavulanate](/Image/AppImage/2205/20161114171736/an262-determination-2ethylhexanoic-acid-impurity-clavulanate?imageNameOnDisk=2205.png)
Description
Clavulanic acid is a potent beta-lactamase inhibitor. 2-ethylhexanoic acid is a potential impurity. This work presents a simpler IC method using a Reagent-Free Ion Chromatography (RFIC) system with suppressed conductivity detection and IonPac AS11 column for the detection and quantification of 2-ethylhexanoic acid. Results for LOD/LOQ, linear calibration range, spike recovery, retention time precision, and peak area precision determinations show that IC is an accurate and reproducible technique to determine 2-ethylhexanoic acid in clavulanate below the 0.8% acceptance criteria.Market: | Pharma |
Keywords: | 2-ethylhexanoic acid, Active pharmaceutical ingredient (API), Anion-exchange, beta-lactamase inhibitor, Ion chromatography, IonPac AS11, Pharmaceutical, Potassium clavulanate, RFIC, Suppressed conductivity |
Matrix: | Drug |
Author: | Richard Kornfeld, Brian De Borba, Jeffrey Rohrer |
For Research Use Only. Not for use in diagnostic procedures.