Approximately 50% of all drugs on the market are developed in salt forms. IC with suppressed conductivity detection plays an important role in the salt selection process to establish correct molecular mass of the entity in early stages of drug development. This study describes the determination of inorganic anions (a) and cations (b) in two different drugs using the capillary Thermo Scientific Dionex ICS-5000 system.

Approximately 50% of all drugs on the market are developed in salt forms. IC with suppressed conductivity detection plays an important role in the salt selection process to establish correct molecular mass of the entity in early stages of drug development. This study describes the determination of inorganic anions (a) and cations (b) in two different drugs using the capillary Thermo Scientific Dionex ICS-5000 system.

Clavulanic acid is a potent beta-lactamase inhibitor. 2-ethylhexanoic acid is a potential impurity. This work presents a simpler IC method using a Reagent-Free Ion Chromatography (RFIC) system with suppressed conductivity detection and IonPac AS11 column for the detection and quantification of 2-ethylhexanoic acid. Results for LOD/LOQ, linear calibration range, spike recovery, retention time precision, and peak area precision determinations show that IC is an accurate and reproducible technique to determine 2-ethylhexanoic acid in clavulanate below the 0.8% acceptance criteria.

The antiretroviral drug tenofovir is in formulation given as the prodrug tenofovir disoproxil fumarate (TDF) in combination with the nucleoside reverse-transcriptase inhibitor emtricitabine. Here we show the impurity profiling of an active pharmaceutical ingredient with the Thermo Scientfic Vanquish Flex UHPLC system. The simultaneous separation of early-eluting polar compounds and later-eluting nonpolar compounds is achieved by applying a ternary gradient with the quaternary Vanquish F pump using a Thermo Scientific Accucore aQ column.

The current trend in antihypertensiion therapy is the medication with several antihypertension agents in a single pill. Here eluent switching capabilities of the Thermo Scientific Vanquish Binary pump H are applied to develop a UHPLC method for simultanous determination of antihypertensive combination agents on a Thermo Scientific Accucore Vanquish C18+ column by scouting different eluent combinations.