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Ternary Gradient for Tenofovir Disoproxil Fumarate Impurity Profiling
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| # | Compound Name | Compound Class | RT (min) |
|---|---|---|---|
| 1 | Adenine | Related Compound | 0.75 |
| 2 | Tenofovir | Related Compound | 1.10 |
| 3 | Emtricitabine | Active pharmaceutical ingredient | 1.92 |
| 4 | Emtricitabine Impurity | Impurity | 2.70 |
| 5 | TDF impurity 1 | Impurity | 3.15 |
| 6 | TDF impurity 2 | Impurity | 3.88 |
| 7 | TDF impurity 3 | Impurity | 3.90 |
| 8 | Tenofovir Disoproxil Fumarate (TDF) | Active pharmaceutical ingredient | 4.46 |
| 9 | TDF impurity 4 | Impurity | 4.73 |
Description
The antiretroviral drug tenofovir is in formulation given as the prodrug tenofovir disoproxil fumarate (TDF) in combination with the nucleoside reverse-transcriptase inhibitor emtricitabine. Here we show the impurity profiling of an active pharmaceutical ingredient with the Thermo Scientfic Vanquish Flex UHPLC system. The simultaneous separation of early-eluting polar compounds and later-eluting nonpolar compounds is achieved by applying a ternary gradient with the quaternary Vanquish F pump using a Thermo Scientific Accucore aQ column.| Market: | Pharma |
| Keywords: | Accucore aQ, Active pharmaceutical ingredients, USP, aqueous gradient, zero percent organic |
| Matrix: | N/A |
| Author: | Susanne Fabel |
| Affiliation: | Thermo Fisher Scientific |
For Research Use Only. Not for use in diagnostic procedures.
