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Ternary Gradient for Tenofovir Disoproxil Fumarate Impurity Profiling
Description
The antiretroviral drug tenofovir is in formulation given as the prodrug tenofovir disoproxil fumarate (TDF) in combination with the nucleoside reverse-transcriptase inhibitor emtricitabine. Here we show the impurity profiling of an active pharmaceutical ingredient with the Thermo Scientfic Vanquish Flex UHPLC system. The simultaneous separation of early-eluting polar compounds and later-eluting nonpolar compounds is achieved by applying a ternary gradient with the quaternary Vanquish F pump using a Thermo Scientific Accucore aQ column.| Market: | Pharma |
| Keywords: | Accucore aQ, Active pharmaceutical ingredients, USP, aqueous gradient, zero percent organic |
| Matrix: | N/A |
| Author: | Susanne Fabel |
| Affiliation: | Thermo Fisher Scientific |
For Research Use Only. Not for use in diagnostic procedures.
