Find methods for your needs

Ternary Gradient for Tenofovir Disoproxil Fumarate Impurity Profiling Be the first to rate this application


The antiretroviral drug tenofovir is in formulation given as the prodrug tenofovir disoproxil fumarate (TDF) in combination with the nucleoside reverse-transcriptase inhibitor emtricitabine. Here we show the impurity profiling of an active pharmaceutical ingredient with the Thermo Scientfic Vanquish Flex UHPLC system. The simultaneous separation of early-eluting polar compounds and later-eluting nonpolar compounds is achieved by applying a ternary gradient with the quaternary Vanquish F pump using a Thermo Scientific Accucore aQ column.
Market: Pharma
Keywords: Accucore aQ, Active pharmaceutical ingredients, USP, aqueous gradient, zero percent organic
Matrix: N/A
Author: Susanne Fabel
Affiliation: Thermo Fisher Scientific
Uploaded on 6/17/2015.

For Research Use Only. Not for use in diagnostic procedures.