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Displaying 1-5 of 13 results for Tag: Accucore aQ

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A rapid cephradine USP assay method

Instrument Type: UHPLC

To demonstrate practical approaches that can be used to significantly improve throughput of the cephradine USP assay monograph keeping to the spirit of USP-NF Chapter <621> guidelines while maintaining USP quality acceptance criteria.

Determination of 24 Pesticide Residues in Red Wine Using a QuEChERS Sample Preparation Approach and LC-MS/MS Detection

Instrument Type: LCMSMS

Red wine is a rich source of phenolic antioxidants and is reported to reduce the risk of diabetes, cancer, Alzheimer's disease, and cardiovascular disease. To improve grape yields it is common practice in vineyards to use pesticides, such as fungicides and insecticides. This application presents a fast, easy, and cost-effective method for the determination of 24 pesticide residues in red wine using the QuEChERS extraction method (AOAC version), cleanup by dispersive solid-phase extraction (dSPE), followed by LC-MSMS analysis.

Ternary Gradient for Tenofovir Disoproxil Fumarate Impurity Profiling

Instrument Type: UHPLC

The antiretroviral drug tenofovir is in formulation given as the prodrug tenofovir disoproxil fumarate (TDF) in combination with the nucleoside reverse-transcriptase inhibitor emtricitabine. Here we show the impurity profiling of an active pharmaceutical ingredient with the Thermo Scientfic Vanquish Flex UHPLC system. The simultaneous separation of early-eluting polar compounds and later-eluting nonpolar compounds is achieved by applying a ternary gradient with the quaternary Vanquish F pump using a Thermo Scientific Accucore aQ column.

Accurate determination of atorvastatin impurities using reversed-phase HPLC-UV

Instrument Type: HPLC

The Thermo Scientific Dionex UltiMate 3000 LC system is applied for the analysis of atorvastatin impurities. The separation was performed on a Thermo Scientific Accucore aQ HPLC column using a reversed-phase method with UV detection at 254 nm.

Purity and mass determination using Thermo Scientific Accucore aQ HPLC columns: a column lifetime study

Instrument Type: HPLC

A fast and reliable separation for quality control of small molecule drug candidates is demonstrated using Thermo Scientific Accucore aQ HPLC columns. The method run time was 3.25 minutes with each compound adequately resolved. The excellent peak shape was maintained for more than 11000 injections.