Find methods for your needs

Refine by Feature

No filters available

Displaying 1-1 of 1 results for Tag: beta-lactamase inhibitor

Items per page:
Sort by

AN262: Determination of 2-Ethylhexanoic Acid Impurity in Clavulanate

Instrument Type: IC

Clavulanic acid is a potent beta-lactamase inhibitor. 2-ethylhexanoic acid is a potential impurity. This work presents a simpler IC method using a Reagent-Free Ion Chromatography (RFIC) system with suppressed conductivity detection and IonPac AS11 column for the detection and quantification of 2-ethylhexanoic acid. Results for LOD/LOQ, linear calibration range, spike recovery, retention time precision, and peak area precision determinations show that IC is an accurate and reproducible technique to determine 2-ethylhexanoic acid in clavulanate below the 0.8% acceptance criteria.