低分子肝素（low-molecular-weight heparin， LMWH） 是近年发展起来的新一代肝素类抗血栓药物， 其抗血栓作用优于肝素，而抗凝血作用低于肝素，且具有 皮下注射吸收良好、生物利用度高、体内半衰期长、出血 倾向小等优点，目前已广泛应用于临床。根据LMWH的来 源、生产工艺、末端结构的不同，LMWH 分为许多不同 的种类，如达替肝素钠、依诺肝素钠、那曲肝素钙、帕米 肝素钠、汀肝素钠等。达替肝素钠（Dalteparin Sodium） 是低分子肝素的一种，由亚硝酸降解肝素得到，重均分子 量5600～6400，峰位分子量6000，硫酸化程度为2.0～ 2.5/双糖单位[1]。 本实验使用高效阴离子交换色谱法测定游离硫酸根含 量，灵敏度高、选择性好、快速。

SBE-β-CD样品基体相对简单，干扰较少，易于分 离。安培检测器可进一步提高方法的选择性。方法前处 理简单，样品水稀释后即可直接进样分析，样品谱图见图 1。方法线性良好，灵敏度高，重现性好。

Determination of sulfamate and sulfate are used to monitor and confirm topiramate degradation. In application note 238 we demonstrate the use of a Reagent-Free Ion Chromatography (IC) system with a Thermo Scientific Dionex IonPac AS11 column and suppressed conductivity detection for the determination of sulfamate and sulfate in topiramate. This record shows that the method can be run using a new compact IC system: the Thermo Scientific Dionex Integrion system.

Citric acid is a common ingredient found in pharmaceutical formulations. An assay for citrate and phosphate in pharmaceutical formulations using ion chromatography with a Thermo Scientific Dionex IonPac AS11 hydroxide-selective, anion-exchange column and suppressed conductivity detection was validated in Application Note 164. The method incorporates an electrolytic eluent generator to automatically produce an isocratic potassium hydroxide eluent. This record shows that the method can be run using the Thermo Scientific Dionex Integrion system.

A platform using Dionex ion chromatography (IC) coupled to triple quadrupole mass spectrometry (MS) was developed to measure various metabolites in Brassica napus seeds. The IC tandem mass spectrometry (IC-MS/MS) technique provides a good tool to identify and quantify metabolites in a complex matrix.