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Metoprolol and EP Impurities M and N analyzed using HILIC chromatography and Charged Aerosol Detection
Description
Metoprolol succinate, a selective beta1-adrenoreceptor antagonist, reduces chest pain and lowers high blood pressure. Impurity profiling of a drug substance is important since even at small amounts they may influence product efficacy and safety. Metoprolol analysis by LC/UV detection has been described but some impurities do not possess a chromophore. The European Pharmacopeia specifies thin layer chromatography for impurities M and N analysis. This does not produce reliable quantitative data. The USP monograph modernization program indicates that a chromatographic method is more desirable.| Market: | Pharma |
| Keywords: | Vanquish UHPLC, Charged Aerosol Detection, Impurity, Metoprolol |
| Matrix: | Acetonitrile |
| Author: | Bruce Bailey |
| Affiliation: | Thermo Scientific, CMD |
For Research Use Only. Not for use in diagnostic procedures.
