The biopharmaceutical industry continues to develop protein-based biotherapeutics in increasing numbers. Due to their complexity and biotechnological production, there are many attributes that need to be analyzed to guarantee their safety and efficacy. Peptide mapping is used to measure several critical quality attributes (CQA) required for the characterization of any biotherapeutic protein. The analysis is used to confirm that the correct sequence has been expressed for the protein and to check for post-translational and chemical modifications.

There is increasing demand to provide rapid and selective screening techniques for a wide range of antibiotic drugs. Their abuse as a feed supplement in food animals is of growing concern and is subject to regulations globally. Creating screening methods for multiple analytes is more cost effective than dedicated methods for fewer analytes. This application shows the advantages of using the Thermo Scientific Accucore Vanquish C18 UHPLC 1.5 µm column and Vanquish UHPLC system for the analysis of thirty-six antibiotics.

This application shows the advantages of using the Thermo Scientific™ Hypersil GOLD aQ VANQUISH™ 1.9 µm column and Thermo Scientific™ Vanquish™ UHPLC system, for the fast analysis of sulfur-containing drugs. The built-in method scaling of the Chromeleon software and high pressure capabilities of the Hypersil GOLD VANQUISH columns, that allow operation at higher flow rates,enable the development of rapid analytical methods whilst maintaining high performance.

To demonstrate the advantages of using the Thermo Scientific™ Hypersil GOLD™ VANQUISH, 1.9 µm column and Thermo Scientific™ Vanquish™ UHPLC system, for the fast analysis of 13 antiretroviral compounds.

To provide an application for the analysis of statins using the Thermo Scientific™ Hypersil GOLD VANQUISH™ 1.9 µm column and Thermo Scientific™ Vanquish H™ UHPLC system, exploiting the non-linear gradient capability of the systemDemonstrate the opportunity for increased throughput by operating at higher flow rates and backpressures