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Displaying 1-3 of 3 results for Tag: Acetonitrile
AU133: Saccharin in Electrolytic Nickel Sulfate BathsInstrument Type: IC
Saccharin decreases the tensile strength of electrolytic nickel deposits and can, with increasing concentrations, cause compressive stress. Determination of saccharin by ion chromatography is faster and has fewer interferences than classical titrimetric methods of analysis.
USP 467 analysis of residual solvents using GC-FID with headspaceInstrument Type: GC
The Thermo Scientific TRACE GC Ultra is applied for the analysis of residual solvents by USP method 467. The separation was performed on a Thermo Scientific TRACE TR-V1 GC column, with flame ionization detection.
Metoprolol and EP Impurities M and N analyzed using HILIC chromatography and Charged Aerosol DetectionInstrument Type: UHPLC
Metoprolol succinate, a selective beta1-adrenoreceptor antagonist, reduces chest pain and lowers high blood pressure. Impurity profiling of a drug substance is important since even at small amounts they may influence product efficacy and safety. Metoprolol analysis by LC/UV detection has been described but some impurities do not possess a chromophore. The European Pharmacopeia specifies thin layer chromatography for impurities M and N analysis. This does not produce reliable quantitative data. The USP monograph modernization program indicates that a chromatographic method is more desirable.