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AN1075: Ion Chromatography Assay for Chloride and Sulfate in Adenosine
Description
Adenosine is produced by the condensation of ribose and adenine biochemically or by fermentation. Anions such as chloride and sulfate are possible impurities in adenosine preparations and the U.S. Pharmacopeia (USP) adenosine monograph describes turbidity-based assays to determine the amount of chloride and sulfate in adenosine which are subjective, use toxic chemicals, and generate hazardous waste. This application is a fast ion chromatography (IC)-based method that can meet the assay requirements and replace the USP adenosine monograph’s existing turbidity-based assays.| Market: | Pharma |
| Keywords: | Pharmaceutical, Adenosine, Drug Products, Impurities, Reagent-Free Ion Chromatography, Dionex IonPac AS18-4 μm, Fast Separation, RFIC, Chloride, Sulfate, Suppressed Conductivity, AN 1075, AN 70854, AN70854 |
| Matrix: | Drug |
| Author: | Lipika Basumallick and Jeffrey Rohrer |
| Affiliation: | Thermo Fisher Scientific, Sunnyvale, CA USA |
For Research Use Only. Not for use in diagnostic procedures.
