AN1075: Ion Chromatography Assay for Chloride and Sulfate in Adenosine
DescriptionAdenosine is produced by the condensation of ribose and adenine biochemically or by fermentation. Anions such as chloride and sulfate are possible impurities in adenosine preparations and the U.S. Pharmacopeia (USP) adenosine monograph describes turbidity-based assays to determine the amount of chloride and sulfate in adenosine which are subjective, use toxic chemicals, and generate hazardous waste. This application is an fast ion chromatography (IC)-based method that can meet the assay requirements and replace the USP adenosine monograph’s existing turbidity-based assays.
|Keywords:||Adenosine, Chloride, Dionex IonPac AS18-4 μm, Drug Products, Fast Separation, Impurities, Pharmaceutical, Reagent-Free Ion Chromatography, RFIC, Sulfate, Suppressed Conductivity|
For Research Use Only. Not for use in diagnostic procedures.