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AN246: Determination of Diethylene Glycol in a Sorbitol Solution
Description
Glycerin, sorbitol, and propylene glycol (PG) are widely used in pharmaceuticals and personal care products. These products are at risk from adulteration by similar, less costly, and very toxic compounds (ethylene glycol (EG) and diethylene glycol (DG)). The United States Pharmacopeia (USP) as directed by the US FDA revised USP 32 NF 26–27 monographs to identify and quantify EG and DEG in PG, sorbitol, and glycerin solutions. Here DEG in sorbitol solution is determined by IC-PAD with Pt working electrode. An ICS-6000 can be used for this application.| Market: | Pharma |
| Keywords: | EG, Ethylene glycol, ion exclusion chromatography, IonPac CS14, propylene glycol, diethylene glycol, ICS-5000+ HPIC system, mixed mode separation, IonPac ICE-AS1, DEG, Glycerol, Sorbitol, PAD, ICE, Cation Exchange, ICS-6000 |
| Matrix: | Sorbitol solution |
| Author: | Terri Christison, Brian De Borba, and Jeff Rohrer |
| Affiliation: | Thermo Fisher Scientific |
For Research Use Only. Not for use in diagnostic procedures.
