AN117: Quantification of Carbohydrates and Glycols in Pharmaceuticals - Alditols and Small Carbohydrates Method

Instrument Type: IC

Two oral, over-the-counter medications were evaluated as representative pharmaceutical products. A cough suppressant and a multisymptom cold/flu medication were chosen because they contain a complex mixture of simple sugars, glycols,and sugar alcohols. These carbohydrates and glycols are also commonly found in other medications. This method uses the CarboPac MA1 column to retain and separate the target analytes.

AN117 - Quantification of Carbohydrates and Glycols in Pharmaceuticals - Glycols Method

Instrument Type: IC

This application note describes the use of three different anion-exchange columns with amperometric detection to analyze common simple sugars, sugar alcohols, and glycols in pharmaceutical formulations. The method in this entry shows how to determine glycols using ion-exclusion chromatography on Dionex ICE-AS1 column.

AN246: Determination of Diethylene Glycol in a Sorbitol Solution

Instrument Type: IC

Glycerin, sorbitol, and propylene glycol (PG) are widely used in pharmaceuticals and personal care products. These products are at risk from adulteration by similar, less costly, and very toxic compounds (ethylene glycol (EG) and diethylene glycol (DG)). The United States Pharmacopeia (USP) as directed by the US FDA revised USP 32 NF 26–27 monographs to identify and quantify EG and DEG in PG, sorbitol, and glycerin solutions. Here DEG in sorbitol solution is determined by IC-PAD with Pt working electrode. An ICS-6000 can be used for this application.