AN246: Determination of Diethylene Glycol in a Sorbitol Solution

Instrument Type: IC

Glycerin, sorbitol, and propylene glycol (PG) are widely used in pharmaceuticals and personal care products. These products are at risk from adulteration by similar, less costly, and very toxic compounds (ethylene glycol (EG) and diethylene glycol (DG)). The United States Pharmacopeia (USP) as directed by the US FDA revised USP 32 NF 26–27 monographs to identify and quantify EG and DEG in PG, sorbitol, and glycerin solutions. Here DEG in sorbitol solution is determined by IC-PAD with Pt working electrode. An ICS-6000 can be used for this application.

AN246: Determination of Ethylene Glycol in a Sorbitol Solution

Instrument Type: IC

Glycerin, sorbitol, and propylene glycol (PG) are widely used in pharmaceuticals and personal care products. These products are at risk from adulteration by similar, less costly, and very toxic compounds (ethylene glycol (EG) and diethylene glycol (DG)). The United States Pharmacopeia (USP) as directed by the US FDA revised USP 32 NF 26–27 monographs to identify and quantify EG and DEG in PG, sorbitol, and glycerin solutions. Here EG in sorbitol solution is separated by HPAE on CarboPac MA1 column, optimized for the separation of sugar alcohols and detected by PAD with Au working electrode.

GC-MS analysis of diethylene glycol and ethylene glycol in toothpaste using a Thermo Scientific TraceGOLD TG-WaxMS column

Instrument Type: GCMS

The Thermo Scientific GC system is applied for the analysis of diethylene glycol and ethylene glycol in toothpaste. The separation is performed using a Thermo Scientific TraceGOLD TG-WaxMS column with 5m SafeGuard.