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AN246: Determination of Ethylene Glycol in a Sorbitol Solution
Description
Glycerin, sorbitol, and propylene glycol (PG) are widely used in pharmaceuticals and personal care products. These products are at risk from adulteration by similar, less costly, and very toxic compounds (ethylene glycol (EG) and diethylene glycol (DG)). The United States Pharmacopeia (USP) as directed by the US FDA revised USP 32 NF 26–27 monographs to identify and quantify EG and DEG in PG, sorbitol, and glycerin solutions. Here EG in sorbitol solution is separated by HPAE on CarboPac MA1 column, optimized for the separation of sugar alcohols and detected by PAD with Au working electrode.Market: | Food and Beverage |
Keywords: | Electrochemical detection, Ethylene glycol, Sugar alcohols, NaOH, CarboPac MA1 column, Sorbitol solution, alternative USP 32 NF 26–27 monographs, alternative USP Ethylene Glycol monograph, glycerin, Glycerol, Sorbitol, HPAE-PAD, TN71, TN 20, TN 70671, TN20, TN70671, AN 246 |
Matrix: | Sorbitol solution |
Author: | Terri Christison, Brian De Borba, and Jeff Rohrer |
Affiliation: | Thermo Fisher Scientific, Sunnyvale, CA USA |
For Research Use Only. Not for use in diagnostic procedures.