AN246: Determination of Ethylene Glycol in a Sorbitol Solution

Instrument Type: IC

Glycerin, sorbitol, and propylene glycol (PG) are widely used in pharmaceuticals and personal care products. These products are at risk from adulteration by similar, less costly, and very toxic compounds (ethylene glycol (EG) and diethylene glycol (DG)). The United States Pharmacopeia (USP) as directed by the US FDA revised USP 32 NF 26–27 monographs to identify and quantify EG and DEG in PG, sorbitol, and glycerin solutions. Here EG in sorbitol solution is separated by HPAE on CarboPac MA1 column, optimized for the separation of sugar alcohols and detected by PAD with Au working electrode.