Tobramycin is an important aminoglycoside antibiotic used in ophthalmic and intravenous treatments to treat bacterial infections by blocking protein synthesis.[1] Determinations of tobramycin, kanamycin and other aminoglycoside antibiotics have been previously demonstrated by HPAE-IPAD since 2004.[2–6] This document updates Thermo Scientific™ Application Note 61 using a highpressure-capable Dionex Integrion HPIC system equipped with updated EG technology and an electrochemical detector.

In the electronics industry, ionic contamination in the range of parts per trillion (ppt, ng/L) to parts per billion (ppb) concentrations is a major concern, causing corrosion-related failures in production and final product. Ionic contamination is increasingly important as the devices decrease to size. This technical note demonstrates automated calibration and water purification on an ICS-5000+ HPIC dual IC system to minimize the system and environmental contamination which resulted in increased sensitivity to double-digit-ppt concentrations. An ICS-6000 can be used for this application.

In the electronics industry, ionic contamination, in the range of parts per trillion (ppt, ng/L) to parts per billion (ppb) concentrations, is a major concern causing corrosion-related failures in production and as a product. Ionic contamination is increasingly important as the devices decrease to size. This technical note demonstrates automated calibration and water purification on an ICS-5000+ HPIC dual IC system to minimize the system and environmental contamination which resulted in increased sensitivity to double-digit-ppt concentrations. An ICS-6000 can be used for this application.

Determinations of trace anions in ultrapure water are important to the electronics industry. In this record, determinations of ng/L (ppt) anions using large volume concentration are made possible by the Electrolytic Water Purifier(EWP) and AutoPrep modules. Calibration standards are prepared using the AutoPrep large and small loops and EWP-purified water diluent, thereby increasing sensitivity by eliminating sources of contamination. The trace anions are separated on an IonPac AS17-C column designed to improve low level sulfate determinations using a Dionex Integrion compact IC system.

Determinations of trace anions in ultrapure water are important to the electronics industry. In this record, determinations of ng/L (ppt) anions using large volume concentration are made possible by the Electrolytic Water Purifier(EWP) and AutoPrep modules. Calibration standards are prepared using the AutoPrep large and small loops and EWP-purified water diluent, thereby increasing sensitivity by eliminating sources of contamination. The trace anions are separated on an IonPac AS17-C column designed to improve low level sulfate determinations using a Dionex Integrion compact IC system.