The IC-based method described in this application note uses a Thermo Scientific Dionex IonPac CS16 cation-exchange column, an electrolytically generated MSA eluent, and suppressed conductivity detection to determine lithium in lithium hydroxide. The method proposed in this application note was validated following the guidelines outlined in USP General Chapter <1225>, Validation of Compendial Procedures to meet the requirements for lithium and calcium quantification prescribed in the lithium hydroxide USP monograph. An ICS-6000 can be used for this application.

Inorganic cations were determined in municipal wastewater samples using a high pressure capillary IC system. All six cations were separated on IonPac CS16 capillary column at 30 mM MSA and 40 C. The high pressure capabilities of the ICS-5000+ capillary IC system were demonstrated by using flow rates at 3x of the typical capillary flow rate, 30 uL/min. The separation at the standard flow rate of 10 uL/min is also shown. An ICS-6000 can be used for this application.

A simple ion chromatography method for the direct determination of inorganic cations in drinking water by Reagent Free ICS 5000 plus system, requiring only deionized water to electrolytically produce a MSA eluent. The method in this record is the Quality Assurance Report (QAR) method, and therefore can be used to test the performance of a Dionex IonPac CS16 column.

Choline and acetylcholine are quaternary ammonium cations which are noted for their activities as neurotransmitters. This is an older application note that shows these compounds can be determined by IC. Today we would probably use an IonPac CS19 column as shown in Application Update 189.

This work demonstrates the determination of the API (amphetamine) and counterions (aspartate, saccharin and sulfate) in a medicine Adderall within a single analysis using a Thermo Scientific Acclaim Trinity P2 column and Thermo Scientific Dionex Corona Veo Charged Aerosol Detector (CAD).