Find methods for your needs
Refine by Feature
Displaying 1-5 of 10 results for Tag: Anticonvulsant
Trace analysis of pharmaceuticals and organic contaminants in waterInstrument Type: LCMSMS
We present the reliable and accurate quantitative analysis of contaminants at the pg/mL level in drinking water using the Thermo Scientific EQuan MAX Plus LC-MS system coupled to the Thermo Scientific TSQ Endura triple quadrupole mass spectrometer. Excellent reproducibility was shown for the target compounds in tap water using 1 mL injections at 0.37× maximum effluent concentration.
Forensic Screening for Drugs in Urine Using High-Resolution MS/MS Spectra and Simplified High-Performance Screening SoftwareInstrument Type: LCMSMS
Forensic toxicologists need an economical solution to screen for a virtually unlimited number of compounds in urine. Here we present a method for screening using a dilute-and-shoot approach with the Q Exactive Focus mass spectrometer and Thermo Scientific ToxFinder software. For forensic use only.
Quantitation of 122 Drugs in Urine by Triple Quadrupole Mass SpectrometryInstrument Type: LCMSMS
Forensic toxicologists face an ever-expanding list of compounds for analysis. This note presents work done using a next-generation triple quadrupole mass spectrometer with fast SRM acquisition speed for quantitation of 122 analytes in a single chromatographic run, where scan speed does not impact sensitivity or quantitative performance. Compounds analyzed include opiates, opioids, benzodiazepines, barbiturates, amphetamines, tricyclic antidepressants, illicit compounds, and more. For forensic use only.
Quantification of EPA 1694 Pharmaceuticals and Personal Care Products in Water at the ng/L Level Utilizing Online Sample Preparation with LC-MS/MSInstrument Type: LCMSMS
There is growing environmental concern regarding the health impact of trace levels of pharmaceuticals and personal care products (PPCPs) in water resources. In response, the U.S. Environmental Protection Agency (EPA) published Method 1694, which determines dozens of PPCPs in water, soil, sediment, and biosolids by HPLC-MS/MS. We demonstrate a progressive approach to analyzing PPCPs in environmental sources of water at the ng/L level with online sample preparation using small volumes of water, thus saving time and reducing the cost of analysis.
USP 38 monograph: impurity determination of carbamazepine using a cyano HPLC columnInstrument Type: HPLC
The Thermo Scientific Dionex UltiMate 3000 LC system is applied for the analysis of carbamazepine and its impurities. The separation was performed on a Thermo Scientific Hypersil Gold CN HPLC column using the method described in the USP 38 monograph. The results obtained for resolution exceeded the criteria stated in the USP. Resolution between carbamazepine related compound A and carbamazepine was 4.00 (USP criteria of not less than 1.70).