To describe an accurate and precise high-throughput analytical technique for the analysis of methylmalonic acid (MMA) utilizing Thermo Scientific SOLAµ WAX followed by LC-MS/MS. This technique further separates MMA from the known endogenous interference succinic acid (SA), a compound that has the same molecular weight as MMA and demonstrates a similar fragmentation pattern, which can cause issues with selectivity in mass spectrometry (MS) detection. For Research Use Only. Not for use in diagnostic procedures.

The Thermo Scientific system is applied for the analysis of alkyl quaternary amines. The separation is performed on a Thermo Scientific Acclaim Surfactant Plus HPLC column, with suppressed conductivity detection.

The Thermo Scientific UltiMate 3000 LC system is applied for the analysis of laureth sulfate and coco-amidopropyl betaine in shampoos. The separation is performed on a Thermo Scientific Acclaim Surfactant Plus column, with charged aerosol detection.

The Thermo Scientific UltiMate 3000 RSLC system is applied for the analysis of two laundry detergents. The separation is performed on a Thermo Scientific Acclaim Surfactant Plus column, with charged aerosol detection.

The Thermo Scientific UltiMate 3000 RSLC system is applied for the analysis of ethoxylated laurly sulfates. The separation is performed on a Thermo Scientific Acclaim Surfactant Plus column, with charged aerosol detection.