Fast and reliable method for the analysis of methylmalonic acid from human plasma
DescriptionTo describe an accurate and precise high-throughput analytical technique for the analysis of methylmalonic acid (MMA) utilizing Thermo Scientific SOLAµ WAX followed by LC-MS/MS. This technique further separates MMA from the known endogenous interference succinic acid (SA), a compound that has the same molecular weight as MMA and demonstrates a similar fragmentation pattern, which can cause issues with selectivity in mass spectrometry (MS) detection. For Research Use Only. Not for use in diagnostic procedures.
|Keywords:||Acclaim Surfactant Plus, LC-MS/MS, Methylmalonic acid (MMA), Micro-elution, Mixed-mode ion-exchange, SOLAμ WAX, SPE, Succinic acid (SA)|
|Author:||Jon Bardsley, James Goldberg|
|Affiliation:||Thermo Fisher Scientific|
For Research Use Only. Not for use in diagnostic procedures.