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Fast and reliable method for the analysis of methylmalonic acid from human plasma
Description
To describe an accurate and precise high-throughput analytical technique for the analysis of methylmalonic acid (MMA) utilizing Thermo Scientific SOLAµ WAX followed by LC-MS/MS. This technique further separates MMA from the known endogenous interference succinic acid (SA), a compound that has the same molecular weight as MMA and demonstrates a similar fragmentation pattern, which can cause issues with selectivity in mass spectrometry (MS) detection. For Research Use Only. Not for use in diagnostic procedures.| Market: | Clinical Research |
| Keywords: | Acclaim Surfactant Plus, LC-MS/MS, Methylmalonic acid (MMA), Micro-elution, Mixed-mode ion-exchange, SOLAμ WAX, SPE, Succinic acid (SA) |
| Matrix: | Human plasma |
| Author: | Jon Bardsley, James Goldberg |
| Affiliation: | Thermo Fisher Scientific |
For Research Use Only. Not for use in diagnostic procedures.
