Fast and reliable method for the analysis of methylmalonic acid from human plasma

Instrument Type: LCMSMS

To describe an accurate and precise high-throughput analytical technique for the analysis of methylmalonic acid (MMA) utilizing Thermo Scientific SOLAµ WAX followed by LC-MS/MS. This technique further separates MMA from the known endogenous interference succinic acid (SA), a compound that has the same molecular weight as MMA and demonstrates a similar fragmentation pattern, which can cause issues with selectivity in mass spectrometry (MS) detection. For Research Use Only. Not for use in diagnostic procedures.