Pesticide contamination in food as a potential health risk is a growing public concern. The determinations of cationic quaternary amine polar pesticides are challenging due to their similar chemistries and similar masses and mass fragments. For example, Thermo Scientific Dionex™ IonPac™ CS21-Fast-4μm cation-exchange column was designed to resolve diquat and paraquat. This technical note provides the IC-MS conditions for twelve of the fifteen analytes. Three analytes, 1,2,4-triazole, difenzoquat, and propamocarb, are unsuitable using the Dionex IonPac CS21-Fast-4μm column for IC-MS analysis.
Optimization and validation of a multi-residue LC-MS/MS method for pesticides in spinach and cabbage by using Thermo Scientific Vanquish UHPLC and TSQ Quantis mass spectrometer. Sample preparation was performed using QuEChERS method that provided high recoveries for an extensive scope of pesticides in several simple steps. Data acquisition and processing were carried out using Thermo Scientific TraceFinder software. The optimized method was validated as per the SANTE guideline and applied to real samples demonstrating that the workflow is fit for purpose.
Multi-residue instrumental method that can be applied for high-throughput quantitation of pesticide residues in garlic and cumin at or below the current legislative requirements. The Thermo Scientific Orbitrap Exploris 120 mass spectrometer was operated in two different workflows: using full-scan Data-Independent Acquisition for quantitation and confirmation and using Thermo Scientific AcquireX intelligent data acquisition background exclusion workflow for full spectrum filtering, retrospective analysis, and multi-parameter-based compound identification.
A robust, sensitive, and reliable multi-residue LC-MS/MS method workflow solution that uses the Thermo Scientific TSQ Altis triple quadrupole mass spectrometer provides analysis and quantitation of more than 160 veterinary drugs with the Thermo Scientific VetDrugs Explorer Collection solution in salmon (fillet), bovine muscle, and milk. The complete instrument and data processing method including SRM settings is included with the VetDrugs Explorer Collection start-to-finish workflow solution. In 17 minutes, the target veterinary drugs were detected and quantified in food matrices.
We present a multi-residue instrumental method that can be applied for high-throughput screening and semi-quantitation of pesticide residues in food matrices at or below the current legislative requirements. A high-resolution, accurate-mass mass spectrometer operated in Full Scan – Variable Data-Independent Analysis (FS-vDIA)* mode provided an option for full spectrum filtering, retrospective analysis, and multi-parameter-based compound identification. The method was validated for 328 target pesticides, with an option for the future extension to a larger number. (*vDIA not available in US.)
