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Analyzing Residual Solvents in Pharmaceutical Products Using GC Headspace with Valve-and-Loop Sampling Be the first to rate this application

analyzing residual solvents pharmaceutical products using gc headspace with valveandloop sampling

Description

This application note describes the analysis of residual solvents in accordance with USP method <467> using the Thermo Scientific™ TRACE™ 1310 GC, the new Thermo Scientific™ TriPlus™ 300 Headspace autosampler, and the Thermo Scientific™ Dionex™ Chromeleon™ chromatography data system (CDS) software. The method details the chromatographic system and analytical conditions to be used and addresses the acceptable limits for each solvent.
Market: Pharma
Keywords: Excipients, Residual solvents, headspace analysis, USP Method <467>, valve and loop sampling
Matrix: Excipients in water, Pharmaceuticals
Author: Andrea Caruso, Massimo Santoro
Affiliation: Thermo Fisher Scientific
Uploaded on 11/26/2015.

For Research Use Only. Not for use in diagnostic procedures.

Tags

Alcohol Aromatic hydrocarbon Chlorinated Aromatic Hydrocarbon Chlorinated Hydrocarbon Cyclic Hydrocarbon Ether excipient GC headspace analysis Heterocyclic Aromatic Hydrocarbon Heterocyclic Hydrocarbon Hydrocarbon Ketone Nitroalkane Organic Nitrile Pharma pharmaceuticals and Excipient in Water Residual Solvents USP 467 valve and loop sampling
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