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AN284: Determination of Ethyl Sulfate Impurity in Indinavir Sulfate Drug Using Ion Chromatography
Description
Indinavir sulfate is a specific and potent inhibitor of HIV-1 protease that may contain ethyl sulfate as a process contaminant. The work here shows an IC method to measure ethyl sulfate in indinavir sulfate. This method uses a Thermo Scientific Dionex IonPac AS12A column with a carbonate/bicarbonate eluent to separate ethyl sulfate from other anions, including sulfate. The eluent was produced using an eluent generator to improve ease of use and retention time reproducibility.| Market: | Pharma |
| Keywords: | Degradation Products, EGC Carbonate mixer, EPM Electrolytic pH Modifier, Ethyl Sulfate, Nitrate, RFIC, Chloride, Sulfate, IonPac AS12A, Drug Product, ethylsulfate |
| Matrix: | Drug |
| Author: | Thunyarat Phesatcha, Suparerk Tukkeeree, Jeff Rohrer |
| Affiliation: | Thermo Fisher Scientific |
For Research Use Only. Not for use in diagnostic procedures.
