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AN199: Determination of N-Methylpyrrolidine in Cefepime Using a Reagent-Free Ion Chromatography System Be the first to rate this application

an199 determination nmethylpyrrolidine cefepime using a reagentfree ion chromatography system


This application note describes a cation-exchange chromatography method that significantly reduces the time between injections relative to the current USP method (by approximately 3 h) due to the very low hydrophobic character of the IonPac® CS17 column, enabling a faster elution of strongly retained compounds (e.g., cefepime). The linearity, detection limits, precision, and recovery of NMP in cefepime hydrochloride are determined. The limit of quantitation for this method is approximately 0.001% NMP, well within the limit of 0.3% set in the USP method.
Market: Pharma
Keywords: Abdominal infections, Cefepime, Cefepime for Injection, Cefepime hydrochloride, Cephalosporins, febrile neutropenia, IonPac CS17, Maxipime, NF, pneumonia, RFIC, Soft-tissue infections, Urinary tract infections, USP monograph
Matrix: Water
Uploaded on 2/2/2015.

For Research Use Only. Not for use in diagnostic procedures.