Find methods for your needs

Refine by Feature

No filters available

Displaying 1-1 of 1 results for Tag: NF

Items per page:
Sort by

AN199: Determination of N-Methylpyrrolidine in Cefepime Using a Reagent-Free Ion Chromatography System

Instrument Type: IC

This application note describes a cation-exchange chromatography method that significantly reduces the time between injections relative to the current USP method (by approximately 3 h) due to the very low hydrophobic character of the IonPac® CS17 column, enabling a faster elution of strongly retained compounds (e.g., cefepime). The linearity, detection limits, precision, and recovery of NMP in cefepime hydrochloride are determined. The limit of quantitation for this method is approximately 0.001% NMP, well within the limit of 0.3% set in the USP method.