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Displaying 1-5 of 25 results for Tag: Urine

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Increased speed and sample throughput of opioid analysis from human urine using micro-elution solid phase extraction

Instrument Type: LCMSMS

To describe a fast and reproducible optimization procedure for the isolation of opioids from human urine utilizing solid phase extraction (SPE). Subsequent analysis was carried out with liquid chromatography separation coupled to triple quadrupole mass spectrometry detection (LC-MS/MS).

Forensic Screening for Drugs in Urine Using High-Resolution MS/MS Spectra and Simplified High-Performance Screening Software

Instrument Type: LCMSMS

Forensic toxicologists need an economical solution to screen for a virtually unlimited number of compounds in urine. Here we present a method for screening using a dilute-and-shoot approach with the Q Exactive Focus mass spectrometer and Thermo Scientific ToxFinder software. For forensic use only.

High-Throughput, Cost-Efficient LC-MS/MS Forensic Method for Measuring Buprenorphine and Norbuprenorphine in Urine

Instrument Type: LCMSMS

Due to its increased abuse, forensic and testing labs test routinely for the presence of buprenorphine and its metabolite norbuprenorphine. To reduce their case backlog, these labs need cost-efficient analytical tests on hundreds of samples. We developed a high-throughput screening and quantitation LC-MS/MS method in which urine samples are quickly prepared and analyzed by a short chromatographic method implemented on a four-channel LC-MS system for improved productivity. For forensic use only.

Quantitation of Opiates to Low ng/mL Levels in Urine for Forensic Use Using an Affordable, High-Resolution, Accurate-Mass Mass Spectrometer

Instrument Type: LCMSMS

Forensic toxicologists need an economical instrument capable of both screening a large number of compounds and quantifying smaller panels to industry-established limits. Here we present a method for quantitation of six opiates - morphine, codeine, hydromorphone, hydrocodone, oxymorphone, and oxycodone - in human urine down to low ng/mL levels. This work was performed on a Q Exactive Focus hybrid quadrupole Orbitrap mass spectrometer. For forensic use only.

Quantitation of Seven Designer Cathinones in Urine Using Q Exactive Mass Spectrometer

Instrument Type: LCMSMS

Substituted cathinones, or “Bath Salts,” have become the latest abused designer drugs. Based on cathinone, a substance found in the African Catha edulis (khat) plant, substituted cathinones are stimulants with amphetamine- and cocaine-like effects. We describe an HPLC-MS method for the forensic toxicological analysis of the three Schedule I cathinones: MDPV, methylone and mephedrone, as well as other substituted cathinones: methedrone, ethylone, butylone and naphyrone in urine with limits of quantitation (LOQs) of 0.5 ng/mL. For forensic use only.