Acesulfame potassium, saccharin, aspartame, and sucralose are all commonly used artificial sweeteners that have been approved for use by the United States Food and Drug Administration (FDA). Sodium cyclamate has been banned in the United States, although it is approved for use in many other countries, including the UK. We demonstrate the use of the Thermo Scientific Accucore RP-MS HPLC column for the rapid analysis of five artificial sweeteners.

Saccharin decreases the tensile strength of electrolytic nickel deposits and can, with increasing concentrations, cause compressive stress. Determination of saccharin by ion chromatography is faster and has fewer interferences than classical titrimetric methods of analysis.

The United States Food and Drug Administration (U.S. FDA) and regulatory agencies in other countries require that pharmaceutical products be tested for composition. This Application Note describes the use of two anion exchange columns with suppressed conductivity detection to analyze common anions in pharmaceutical formulations. Here demonstrate that the IonPac AS11 resolves, in the same injection, common inorganic anions such as fluoride, chloride, bromide, sulfate, nitrate, and phosphate, as well as common organic anions such as benzoate, sorbate, citrate, and saccharin.

The Thermo Scientific UltiMate 3000 RSLC system is applied for the analysis of triclosan in toothpaste. The separation is performed on a Thermo Scientific Acclaim C8 RSLC column, with UV detection at 218 nm.

The Thermo Scientific Acclaim Mixed-Mode WAX-1 column is used for the separation of ingredients in a toothache pain-reliever, with UV detection at 210 nm.