Screening of pesticides, mycotoxins and veterinary drugs is of great importance in regulated environments (e.g. food and animal feed analysis). The use of triple quadrupole MS is popular, but has certain limitations: no post acquisition re-interrogation of data, limited number of compounds per analysis, and no ability to screen for unidentified unknowns. In this work, we show a full scan screening approach using a novel single stage Orbitrap mass spectrometer coupled to U-HPLC, providing high mass accuracy at high resolutions, elemental composition, and resolving co-eluting targets.

Brominated hydrocarbons (BFRs) have been used in various industries for decades. Most chlorinated pesticides (OCs) have been banned in the United States, but their use still occurs in developing countries. The persistence of BFRs and OCs in the environment, potential deleterious activity, makes the detection and monitoring of these compounds an important topic. We propose DART as a simple, rapid, easy-to-use technique; eliminating the need for chromatographic method development, and reducing or eliminating sample preparation, for detection and quantitation of both BFRs and OCs.

Perfluorinated compounds (PFCs) are ubiquitous and persistent pollutants that bioaccumulate in animals and humans. The potential toxicity of these chemicals has fueled efforts to develop robust analytical techniques for measuring low levels of PFCs in human matrices. We describe a quantitative selected reaction monitoring (SRM) assay developed for six PFCs using the Thermo Scientific TSQ Vantage triple-stage quadrupole mass spectrometer (MS) coupled to a PFC-free Thermo Scientific Accela LC system.

There is a growing public concern about potential contamination of water and the environment with anthropogenic compounds and their degradation products and possible negative impacts on nature and public health. We describe a method that uses the Thermo Scientific Q Exactive mass spectrometer with an Accela Open Autosampler to fully automate the analysis of waste water and drinking water for anthropogenic compounds down to low ppt concentration levels without time consuming solid phase extraction.

Nicotinamide adenine dinucleotide (NAD+ /NADH) and nicotinamide adenine dinucleotide phosphate (NADP+ /NADPH) (Figure 1) are important biological compounds that donate and accept electrons in many anabolic and catabolic functions.