This application brief demonstrates a method for detecting common organic acids using a Thermo Scientific™ Dionex™ Integrion™ HPIC™ system with a Thermo Scientific™ Dionex™ IonPac™ AS11-HC-4μm column set and coupled to a Thermo Scientific™ ISQ™ EC single quadrupole mass spectrometer.

Plastic samples can be very difficult to analyze as sample preparation is required to extract analytes or remove interfering matrices, and these sample preparation techniques can be labor intensive. In this application note, we demonstrate that a CIC system can be used for automated qualitative and quantitative analysis of halogens and sulfur in plastic samples. Four plastic samples were analyzed for their chlorine (Cl), bromine (Br), and sulfur (S) content. Method accuracy was evaluated using a polymer certified reference material (ERM EC680k) for Cl,Br, and S.

In this application, crude oil was combusted in the Mitsubishi AQF-2100H system and then analyzed using a Dionex Integrion Ion Chromatography system to determine chloride and sulfate with a Dionex IonPac AS28-4µm anion exchange column. In the chromatogram shown, the chloride concentration was ~17 ppm and sulfate was ~3000 ppm.

Tobramycin is an important aminoglycoside antibiotic used in ophthalmic and intravenous treatments to treat bacterial infections by blocking protein synthesis.[1] Determinations of tobramycin, kanamycin and other aminoglycoside antibiotics have been previously demonstrated by HPAE-IPAD since 2004.[2–6] This document updates Thermo Scientific™ Application Note 61 using a highpressure-capable Dionex Integrion HPIC system equipped with updated EG technology and an electrochemical detector.

Before running any samples, Thermo Scientific recommends that you first confirm the performance of the column by reproducing the lot validation report chromatogram shipped with column. Compare your results with the one reported in the quality assurance report. This record provides an eWorkflow for executing the QAR method on an Integrion HPIC system.