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Displaying 1-5 of 22 results for Tag: Formulation

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Separation of Vitamin C, Vitamin B12, Folic Acid and Vitamin-E from Multivitamin Capsules.

Instrument Type: HPLC

The Thermo Scientific Dionex UltiMate 3000 LC system is applied for the separation of multivitamins (Folic Acid,Vitamins C, B12, and E from a Multivitamin Capsule. The separation was performed on a Thermo Scientific Acclaim Polar Advantage-II HPLC column with a UV detection at 270 nm. With a run time of 35 minutes, the method allows easy separation of Vitamin C, B12, Folic Acid and E from Multivitamin Capsule.

Assay for Citrate and Phosphate in Pharmaceutical Formulations Using a Compact IC System

Instrument Type: IC

Citric acid is a common ingredient found in pharmaceutical formulations. An assay for citrate and phosphate in pharmaceutical formulations using ion chromatography with a Thermo Scientific Dionex IonPac AS11 hydroxide-selective, anion-exchange column and suppressed conductivity detection was validated in Application Note 164. The method incorporates an electrolytic eluent generator to automatically produce an isocratic potassium hydroxide eluent. This record shows that the method can be run using the Thermo Scientific Dionex Integrion system.

Impurity analysis of loratadine formulation using HPLC-UV with an ion-pair method

Instrument Type: HPLC

The Thermo Scientific Dionex Ultimate 3000 HPLC system was applied for the impurity analysis of loratadine in formulation. The Thermo Scientific Hypersil GOLD HPLC column performed the separation of loratadine and its impurities in 55 minutes with UV detection at 254 nm.

AN1142: Determination of Aluminum in OTC Pharmaceutical Products

Instrument Type: IC

Aluminum-containing compounds are used extensively in cosmetics, prescription pharmaceuticals, and OTC drug products. In this application note, we report the validation of an IC method for the determination of aluminum in OTC formulations using a Dionex IonPac CS10 analytical column and postcolumn derivatization with Tiron, followed by UV absorbance detection at 310 nm. The method was evaluated in terms of linearity, precision, accuracy, ruggedness, and limit of quantitation for aluminum. The method was evaluated with antacids and deodorants. An ICS-6000 can be used for this application.

Related substances analysis of ranolazine by reversed-phase HPLC-UV

Instrument Type: HPLC

The impurity analysis of ranolazine was performed using a Thermo Scientific Dionex UltiMate 3000 HPLC system and a Thermo Scientific Accucore C18 HPLC column. The method was performed in 40 minutes with UV detection at 220 nm.