The Thermo Scientific Dionex UltiMate 3000 LC system is applied for the analysis of Lorazepam and its Organic impurities as per its USP method. The analysis was performed on a Thermo Scientific Syncronis C18 L1 HPLC column using the method described in the USP 39 monograph. The results obtained were found to be within acceptance criteria as stated in the USP. Resolution between Lorazepam Rel Comp A and Lorazepam Rel Comp E was 2.55 (USP criteria of not less than 2.0). Tailing Factor for Lorazepam standard solution was found to be 0.95 (USP criteria of not more than 2.0).

Forensic toxicologists need an economical solution to screen for a virtually unlimited number of compounds in urine. Here we present a method for screening using a dilute-and-shoot approach with the Q Exactive Focus mass spectrometer and Thermo Scientific ToxFinder software. For forensic use only.

Forensic laboratories perform bulk substance identification to support investigations in cases involving possession, trafficking, and manufacturing of illicit drugs. A variety of analytical techniques can be used, but mass spectrometry provides methodologies that produce rapid and confident results. We evaluated two analytical workflows using a DART (Direct Analysis in Real Time) ion source coupled to a LTQ XL ion trap mass spectrometer and a Q Exactive Focus hybrid quadrupole- Orbitrap MS. Pharmaceutical pills were analyzed to demonstrate method performance. For forensic use only.

Forensic toxicologists face an ever-expanding list of compounds for analysis. This note presents work done using a next-generation triple quadrupole mass spectrometer with fast SRM acquisition speed for quantitation of 122 analytes in a single chromatographic run, where scan speed does not impact sensitivity or quantitative performance. Compounds analyzed include opiates, opioids, benzodiazepines, barbiturates, amphetamines, tricyclic antidepressants, illicit compounds, and more. For forensic use only.

There is growing environmental concern regarding the health impact of trace levels of pharmaceuticals and personal care products (PPCPs) in water resources. In response, the U.S. Environmental Protection Agency (EPA) published Method 1694, which determines dozens of PPCPs in water, soil, sediment, and biosolids by HPLC-MS/MS. We demonstrate a progressive approach to analyzing PPCPs in environmental sources of water at the ng/L level with online sample preparation using small volumes of water, thus saving time and reducing the cost of analysis.