Forensic toxicologists need an economical solution to screen for a virtually unlimited number of compounds in urine. Here we present a method for screening using a dilute-and-shoot approach with the Q Exactive Focus mass spectrometer and Thermo Scientific ToxFinder software. For forensic use only.

Forensic toxicologists face an ever-expanding list of compounds for analysis. This note presents work done using a next-generation triple quadrupole mass spectrometer with fast SRM acquisition speed for quantitation of 122 analytes in a single chromatographic run, where scan speed does not impact sensitivity or quantitative performance. Compounds analyzed include opiates, opioids, benzodiazepines, barbiturates, amphetamines, tricyclic antidepressants, illicit compounds, and more. For forensic use only.

The Thermo Scientific Dionex UltiMate 3000 HPLC system is applied for the determination of asenapine maleate impurities. The separation is performed on a Thermo Scientific Accucore C8 HPLC column which provides excellent resolution (Rs >12) between asenapine and its cis-isomer impurity.

The Thermo Scientific HPLC system is applied for the analysis of chlorpromazine. The separation is performed on a Thermo Scientific Hypersil GOLD HPLC column, with UV detection at 254 nm.

The Thermo Scientific HPLC system is applied for the analysis of anti-psychotics. The separation is performed on a Thermo Scientific Hypersil GOLD HPLC column, with UV detection at 254 nm.