Forensic Screening for Drugs in Urine Using High-Resolution MS/MS Spectra and Simplified High-Performance Screening Software

Instrument Type: LCMSMS

Forensic toxicologists need an economical solution to screen for a virtually unlimited number of compounds in urine. Here we present a method for screening using a dilute-and-shoot approach with the Q Exactive Focus mass spectrometer and Thermo Scientific ToxFinder software. For forensic use only.

Quantitation of 122 Drugs in Urine by Triple Quadrupole Mass Spectrometry

Instrument Type: LCMSMS

Forensic toxicologists face an ever-expanding list of compounds for analysis. This note presents work done using a next-generation triple quadrupole mass spectrometer with fast SRM acquisition speed for quantitation of 122 analytes in a single chromatographic run, where scan speed does not impact sensitivity or quantitative performance. Compounds analyzed include opiates, opioids, benzodiazepines, barbiturates, amphetamines, tricyclic antidepressants, illicit compounds, and more. For forensic use only.

Separation of artemether and its impurities using reversed-phase HPLC-UV

Instrument Type: HPLC

The Thermo Scientific Dionex UltiMate 3000 system is applied with the Thermo Scientific Accucore XL C18 HPLC column for the separation of artemether and its impurities, artemisine and dihydroartemisinin, using UV detection at 216 nm.

Fast analysis of artesunate and dihydroartemisinin using a Thermo Scientific Syncronis C18 HPLC column

Instrument Type: HPLC

The Thermo Scientific HPLC system is applied for the analysis of artesunate and dihydroartemisinin. The separation is performed on a Thermo Scientific Syncronis C18 HPLC column, with UV detection at 210 nm. Considering the the Cmax of artesunate is 0.09+/-0.04µg/mL and that artesunate lacks an intensive chromaphore for UV absorption, MS detection is required to improved sensitivity. Within this application we will demonstrate an alternative method using a MS -compatible mobile phase.