The Thermo Scientific™ Dionex™ UltiMate 3000 LC system is applied for a related substance analysis of pregabalin. The separation was performed on a Thermo Scientific Accucore PFP 2.6 µm HPLC column with UV detection.

The Thermo Scientific Dionex Ultimate 3000 system is applied for the related substance analysis of atorvastatin and ezetimibe. The separation is performed on a Thermo Scientific Accucore PFP HPLC column, with UV detection at 260 nm.

The Thermo Scientific Dionex Ultimate 3000 system is applied for the related substance analysis of veratrole alcohol. The separation of veratrole alcohol and the five related substances was performed on a Thermo Scientific Accucore PFP column with a run time of less than 20 minutes.

This testing here shows the advantages of using the Thermo Scientific Dionex UltiMate 3000 system with the Thermo Scientific Accucore PFP 2.6 μm column for the separation of all-trans-acitretin and 13-cis-acitretin metabolites with MS detection on the Thermo Scientific TSQ Vantage.

A simple, rapid and sensitive procedure for the determination of pregabalin in human plasma by LC-MS/MS was developed and evaluated. The drug was isolated from a plasma matrix using Thermo Scientific SOLA SCX solid phase extraction material, and the components of the resultant extracts were separated on a Thermo Scientific Accucore PFP HPLC column. Detection was performed on a triple quadrupole mass spectrometer. For Research Use Only. Not for use in diagnostic procedures.