The Thermo Scientific Dionex UltiMate 3000 LC system is applied to the separation of the related impurities of Rasagiline Mesylate. The separation was performed on a Thermo Scientific Accucore C18 HPLC column with UV detection at 210 nm. With a total run time of 30 minutes the method allows separation of all related impurities of Rasagiline Mesylate. In this method the run time was reduced by 50% by using Core shell technology ,still allowing the monitoring of potential late eluting process related impurities.The previous method was of 60 minutes using a fully porous C18 column.

The Thermo Scientific SMART Digest kit was used for the digestion of insulin. A variety of common buffer additives were compared to the SMART Digest buffer. Samples were analyzed on a Thermo Scientific Dionex UltiMate 3000 RSLC system via reversed-phase separation on a Thermo Scientific Accucore C18 column, with UV detection at 280 nm.

The Thermo Scientific Dionex UltiMate 3000 LC system is applied for the analysis of fenpiverinium, pitofenone and dicofenac in formulation. The separation was performed on a Thermo Scientific Accucore C18 HPLC column with UV detection at 210 and 286 nm.

The Thermo Scientific Dionex UltiMate 3000 LC system is applied for the analysis of itraconazole impurities. The separation was performed on a Thermo Scientific Accucore C18 HPLC column with UV detection at 225 nm.

The Thermo Scientific HPLC system is applied for the analysis of ibuprofen and valerophenone. The separation is performed on a Thermo Scientific Accucore C18 column. The method of analysis is based on the USP monograph.