Fast analysis for separation of related Impurities of Rasagiline Mesylate by using Core shell Technology.
DescriptionThe Thermo Scientific Dionex UltiMate 3000 LC system is applied to the separation of the related impurities of Rasagiline Mesylate. The separation was performed on a Thermo Scientific Accucore C18 HPLC column with UV detection at 210 nm. With a total run time of 30 minutes the method allows separation of all related impurities of Rasagiline Mesylate. In this method the run time was reduced by 50% by using Core shell technology ,still allowing the monitoring of potential late eluting process related impurities.The previous method was of 60 minutes using a fully porous C18 column.
|Keywords:||Accucore C18, UV detection, UHPLC, Rasagiline Mesylate, 1-Aminoindan, 1-Indenone, Thermo Gradient Method transfer Calculator|
|Affiliation:||Thermo Fisher Scientific, APAC CoE Lab, Ahmedabad, India|
For Research Use Only. Not for use in diagnostic procedures.