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Fast analysis for separation of related Impurities of Rasagiline Mesylate by using Core shell Technology.

Instrument Type: UHPLC

The Thermo Scientific Dionex UltiMate 3000 LC system is applied to the separation of the related impurities of Rasagiline Mesylate. The separation was performed on a Thermo Scientific Accucore C18 HPLC column with UV detection at 210 nm. With a total run time of 30 minutes the method allows separation of all related impurities of Rasagiline Mesylate. In this method the run time was reduced by 50% by using Core shell technology ,still allowing the monitoring of potential late eluting process related impurities.The previous method was of 60 minutes using a fully porous C18 column.