The goal of this work is to design an ion chromatography (IC) method for the determination of guanidine. A method that uses a Thermo Scientific™ Dionex™ IonPac™ CS20 cation-exchange column, electrolytically generated MSA eluent, and suppressed conductivity detection was developed to determine guanidine in pharmaceutical formulations. The method proposed in this application note was validated following the guidelines outlined in USP General Chapter <1225>, Validation of Compendial Procedures to meet the requirements of a validated guanidine assay.

The goal of this work is to design an ion chromatography method that uses a Dionex IonPac AS28-Fast-4μm anion exchange column, electrolytically generated KOH eluent, and suppressed conductivity detection to determine phosphite and phosphate in ibandronate sodium. The method proposed in this application note was validated following the guidelines outlined in USP General Chapter <1225>, Validation of Compendial Procedures to meet the requirements specified for phosphite and phosphate quantification prescribed in the proposed USP Ibandronate Sodium monograph.

In this application note, a fast method for the determination of lithium salt and its additives has been developed using a Thermo Scientific Dionex Integrion HPIC system. This method realizes the analysis of lithium salt and its additives in only 9 minutes. The method uses a Thermo Scientific Dionex IonPac AS22-Fast-4µm column. This application is suitable for analyses with high sample throughput in the lithium battery industry.

This study described the simultaneous direct determination of glyphosate and AMPA in oat flour by IC-MS. Glyphosate and AMPA can be determined sensitively and accurately using a Dionex IonPac AS19-4 μm column and ISQ EC single quadrupole mass spectrometer. The Reagent-Free ion chromatography system provides excellent reproducibility, thereby yielding greater quantification accuracy and consistently reliable results.

This application note describes a convenient, fast, and sensitive method that uses a Thermo Scientific™ Dionex™ CarboPac™ PA300 column and electrolytic eluent generation. The Dionex CarboPac PA300-4μm column is packed with a new 4 μm particle size supermacroporous resin to achieve high efficiency and high-resolution separations. Using this column, a 16.8 min method that resolved six analytes, including glycol and other carbohydrates, was designed. Results for method linearity, robustness, and accuracy for glycol and carbohydrate quantification in OTC samples are discussed here.