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AN001055: Assay of Guanidine in Pharmaceutical Formulations Be the first to rate this application


The goal of this work is to design an ion chromatography (IC) method for the determination of guanidine. A method that uses a Thermo Scientific™ Dionex™ IonPac™ CS20 cation-exchange column, electrolytically generated MSA eluent, and suppressed conductivity detection was developed to determine guanidine in pharmaceutical formulations. The method proposed in this application note was validated following the guidelines outlined in USP General Chapter <1225>, Validation of Compendial Procedures to meet the requirements of a validated guanidine assay.
Market: Pharma
Keywords: Eluent Generation, HPIC, RFIC, Amine, suppressed conductivity detection, Integrion, ICS-6000, Dionex IonPac CS20 column, Dionex CDRS 600, Dionex EGC 500
Matrix: DI water
Author: Sachin Patil and Jeffrey Rohrer
Affiliation: Thermo Fisher Scientific, Sunnyvale, CA, USA
Uploaded on 7/12/2022.