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HPLC LCMSMS

Environmental Pharma

Yes No

N/A Water

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1,7-Dimethylxanthine 1-OH-Alprazolam 1-OH-Midazolam 4-epi-Chlorotetracycline 4-epi-Tetracycline Acetaminophen Albuterol Alprazolam Ampicillin Anhydroerythromycin Anhydrotetracycline Atenolol Azithromycin Benzoylecgonine Caffeine Carbamazepine Cefotaxime Chlorotetracycline Cimetidine Ciprofloxacin Clarithromycin Cloxacillin Cocaethylene Cocaine Codeine Cotinine Demeclocycline Dextromethorphan** Digoxigenin Digoxin Diltiazem Diphenhydramine Doxycycline Enrofloxacin epiminocycline Erythromycin Flumequine Fluoxetine Impurity A (4-epiminocycline) Lincomycin Lomefloxacin Metformin* Metoprolol Miconazole Midazolam minocycline Nordiazepam Norfloxacin Ofloxacin Oxacillin Oxytetracycline Penicillin-G Penicillin-V Propranolol Ranitidine Roxithromycin Sarafloxacin Sulfachloropyridazine Sulfadiazine Sulfadimethoxine Sulfamerazine Sulfamethazine Sulfamethizole Sulfamethoxazole Sulfathiazole Tetracycline Thiabendazole Trimethoprim Tylosin Unknown impurity 1 Unknown impurity 2 Unknown impurity 3

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Analgesic Analgesic-narcotic Antiacid reflux Antiacid refulx Antiarrythmic Antiarrythmic-benzothiazepine Antibiotic Antibiotic-cephalosporin Antibiotic-fluoroquinolone Antibiotic-macrolide Antibiotic-penicillin Antibiotic-sulfa Antibiotic-tetracycline Anticonvulsant Antidepressant Antidiabetic Antifungal Antihelmintic Antihistamine Antitussive Beta-blocker Bronchodialator Impurity Sedative-benzodiazepine Stimulant tetracycline antibiotic

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Manufacturer

Thermo Fisher Scientific

Model

Acclaim 120 C18 Betasil Hypersil GOLD aQ Hypersil GOLD C8

Stationary Phase

C18 C18 selectivity C18, 120A C8

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Displaying 1-3 of 3 results for: Minocycline

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related substances analysis minocycline

Pharmacopeial assay and related substances analysis of minocycline hydrochloride using a C8 HPLC column

Instrument Type: HPLC

The Thermo Scientific Dionex UltiMate 3000 LC system is applied for the assay and related substances analysis of minocycline hydrochloride. The analysis was performed on a Thermo Scientific Hypersil GOLD C8 HPLC column using the method described in the EP 8.0. The results obtained for resolution and theoretical plates met the criteria stated in the EP. The results obtained for resolution between the peaks due to impurity A and minocycline was 4.3 (EP criteria of minimum 2.0) and theoretical plates for minocycline (0.125 mg/mL) was 6376 (EP criteria of minimum 3000).

minocycline related impurities analysis as per usp

Pharmacopeial assay and organic impurities analysis of Minocycline hydrochloride using a C18 HPLC column

Instrument Type: HPLC

The Thermo Scientific Dionex UltiMate 3000 LC system is applied for assay and organic impurities analysis of minocycline hydrochloride. The analysis was performed on a Thermo Scientific Acclaim 120 C18 HPLC column using the method described in the USP 39 monograph. The results obtained for resolution and tailing factor met the criteria stated in the USP 39. The results obtained for resolution between epiminocycline and minocycline was 7.5 (USP criteria of NLT 4.6) and tailing factor of minocycline (0.5 mg/mL) was 0.94 (USP criteria of 0.9 to 2.0).

quantification epa 1694 pharmaceuticals personal care products water at ngl level utilizing online sample preparation with lcmsms

Quantification of EPA 1694 Pharmaceuticals and Personal Care Products in Water at the ng/L Level Utilizing Online Sample Preparation with LC-MS/MS

Instrument Type: LCMSMS

There is growing environmental concern regarding the health impact of trace levels of pharmaceuticals and personal care products (PPCPs) in water resources. In response, the U.S. Environmental Protection Agency (EPA) published Method 1694, which determines dozens of PPCPs in water, soil, sediment, and biosolids by HPLC-MS/MS. We demonstrate a progressive approach to analyzing PPCPs in environmental sources of water at the ng/L level with online sample preparation using small volumes of water, thus saving time and reducing the cost of analysis.

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