A robust, sensitive, and reliable multi-residue LC-MS/MS method workflow solution that uses the Thermo Scientific TSQ Altis triple quadrupole mass spectrometer provides analysis and quantitation of more than 160 veterinary drugs with the Thermo Scientific VetDrugs Explorer Collection solution in salmon (fillet), bovine muscle, and milk. The complete instrument and data processing method including SRM settings is included with the VetDrugs Explorer Collection start-to-finish workflow solution. In 17 minutes, the target veterinary drugs were detected and quantified in food matrices.
Quinolones, including fluoroquinolones, are a group of synthetic antibacterial compounds used in the treatment of several diseases. The presence of these compounds is an indication of unsafe practices of food production and deficient methods in the production of honey. We developed a sensitive and reproducible LC-MS/MS method for the quantitation of 12 fluoroquinolones and 4 quinolones in honey using automated extraction by TurboFlow technology as an alternative to the commonly used, time-consuming solid-phase extraction (SPE) method.
There is growing environmental concern regarding the health impact of trace levels of pharmaceuticals and personal care products (PPCPs) in water resources. In response, the U.S. Environmental Protection Agency (EPA) published Method 1694, which determines dozens of PPCPs in water, soil, sediment, and biosolids by HPLC-MS/MS. We demonstrate a progressive approach to analyzing PPCPs in environmental sources of water at the ng/L level with online sample preparation using small volumes of water, thus saving time and reducing the cost of analysis.
Antibiotics are widely used to treat diseased animals, prevent diseases and promote growth. However, inappropriate or excessive usage of antibiotics can result in antibiotic residues being found found in food and food products of animal origin. In here, a multi-residue, confirmatory method for the quantitative determination of antibiotics in chicken meat is described using the Thermo Scientific Transcend TLX system coupled to an LC-MS/MS. With online sample cleanup and high sample throughput, this approach addresses the demand for a fast and cost-effective multi-analyte method.
Forty-four multi-class veterinary drugs of known concentrations were employed to demonstrate how the use of a generic variable data-independent acquisition (vDIA) method with wide MS/MS precursor isolation windows achieves sensitivity and selectivity comparable to data-dependent MS2 acquisition (using narrow isolation windows) in quantitative and qualitative small molecule applications. In addition, a full record of MS and MS/MS data for the measured sample fit for non-targeted and unknown screening purposes is delivered. vDIA is not available in the United States of America
